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- Author e-FILLERS Team
- Jul 24th, 2025
Layering Fillers, Polynucleotides & Biostimulators: A 2025 Protocol Guide
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As patient expectations rise, so must treatment sophistication. Aesthetic professionals are moving toward layered injectables—sequencing polynucleotides, hyaluronic acid (HA) fillers, and biostimulators for optimized, long-term rejuvenation. Each product type addresses different aging concerns, making them ideal partners in an integrated protocol. Aging impacts the skin at multiple levels: hydration, fat loss, collagen degradation, and ligament laxity. Treating these symptoms in isolation yields short-lived results. Instead, layered protocols target each level: - Polynucleotides rebuild the skin’s cellular matrix and hydration - Fillers restore structural volume and facial contour - Biostimulators reprogram fibroblasts to regenerate collagen and elastin Start with skin health. Intradermal injections or mesotherapy using PDRNs like Plinest, Nucleofill, or PhilArt improve skin quality, hydration, and fibroblast activity. After the skin is optimized, restore volume and enhance structure. Choose appropriate filler types (high G’ for deep support, soft for superficial correction). Introduce Sculptra (PLLA), Radiesse(CaHA), or newer hybrids. These products trigger neocollagenesis for tissue tightening, dermal thickening, and lifting effects. Week 0: Polynucleotides (face/neck) Week 4: HA filler for cheeks, jawline, lips Week 8: Biostimulator injections for temples, lower face, and décolleté Tailor the protocol to patient age, skin condition, and budget Use spacing to prevent product overlap and optimize absorption Always educate the patient on gradual improvement and follow-up Never inject biostimulators superficially in high-risk areas Use cannulas where appropriate to minimize trauma Watch for immune-reactive skin types—do a test patch for novel products Layering isn’t just a trend—it’s a shift in aesthetic philosophy. By addressing structure, skin quality, and volume over time, practitioners can offer results that look natural, last longer, and truly transform. Thoughtful sequencing and product synergy will define the most successful treatments in 2025 and beyondLayering Fillers, Polynucleotides & Biostimulators: A 2025 Protocol Guide
The Philosophy of Layering
Treatment Roadmap
Step 1 – Skin Priming with Polynucleotides (Week 0)
Step 2 – Volume Correction with HA Fillers (Week 3–4)
Step 3 – Structural Regeneration with Biostimulators (Week 6+)
Example Full-Face Protocol
Tips for Optimal Results
Safety Notes
Conclusion: Building Rejuvenation from the Inside Out
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