-
- Author e-FILLERS Team
- Jun 19th, 2025
How to Build an Effective Filler Protocol by Age Group

Dermal fillers are among the most versatile tools in aesthetic medicine, offering solutions for facial contouring, volume restoration, wrinkle correction, and even skin quality enhancement. However, the ideal filler treatment plan is not one-size-fits-all—it should be tailored to the patient’s age, skin condition, and structural changes over time.
Understanding how to build an effective filler protocol by age group can help aesthetic practitioners deliver natural-looking results, maximize product longevity, and meet evolving patient expectations.
Understanding Aging by Decade
Facial aging occurs gradually, involving volume loss, skin laxity, bone resorption, and soft tissue descent. A protocol that works for a 28-year-old patient focused on prevention will differ significantly from a corrective plan for a patient in their 50s.
Filler Protocol for Ages 20–30: Prevention and Subtle Enhancement
Aesthetic Goals:
Enhance natural features (e.g. lips, jawline, cheeks)
Prevent early signs of aging
Correct asymmetries
Protocol Recommendations:
Lips: Use soft HA fillers like Teosyal Kiss or Juvederm Volbella for hydration and subtle volume
Chin & Jawline Contour: Stylage XL or Aliaxin EV for definition
Skin Quality: Biorevitalizers such as NCTF 135HA to maintain glow and elasticity
Frequency:
Injectables every 6–12 months for volume
Skin boosters every 3–6 months
Notes:
Focus on enhancing rather than correcting
Low-dose, high-frequency protocols help prevent premature aging
Filler Protocol for Ages 30–40: Correction and Early Volume Restoration
Aesthetic Goals:
Address nasolabial folds and tear troughs
Restore midface volume
Maintain skin hydration and firmness
Protocol Recommendations:
Midface Volume: Use medium-density fillers like Restylane Lyft or Aliaxin GP for cheek support
Under-Eyes: Light, hydrating fillers like Teosyal Redensity II for tear trough correction
Skin Rejuvenation: Combine with mesotherapy or polynucleotides (Pluryal Refresh, Sunekos 200)
Frequency:
Volume restoration every 9–12 months
Skin quality maintenance every 3–4 months
Notes:
Start combination treatments (e.g., toxin + filler + skin booster)
Address structural and skin quality changes together
Filler Protocol for Ages 40–50: Structural Support and Contour Rebalancing
Aesthetic Goals:
Correct deepening lines and volume loss
Improve contour in lower face and temples
Lift sagging tissue non-surgically
Protocol Recommendations:
Midface and Temples: High G' fillers like Juvederm Voluma or Stylage L
Lower Face and Jawline: Teosyal RHA 4 or Aliaxin EV for structural integrity
Neck and Perioral Zone: Combine soft fillers with polynucleotides or Sunekos 1200
Frequency:
Structural fillers every 9–15 months
Skin biorevitalization every 2–3 months
Notes:
Prioritize structural lifting before treating superficial wrinkles
Consider full-face assessments to avoid overfilling isolated zones
Filler Protocol for Ages 50+: Restoration and Harmonization
Aesthetic Goals:
Restore lost volume and facial harmony
Soften deep folds and marionette lines
Improve overall skin density and hydration
Protocol Recommendations:
Full Face Restoration: Combination of deep fillers (Volux, Stylage XXL) with mid-layer HA products
Marionette and Nasolabial Folds: Restylane Defyne or Teosyal Deep Lines
Skin Texture: Biostimulators like Sculptra or Gouri alongside fillers
Neck and Décolleté: Sunekos Performa or Pluryal Mesoline Firm
Frequency:
Structural fillers annually
Maintenance touch-ups every 6–9 months
Skin boosters every 2–3 months
Notes:
Avoid overcorrection; prioritize natural rebalancing
Layer treatments over time to allow tissue adaptation
Conclusion
Effective filler protocols must evolve with the patient's age, anatomical needs, and personal goals. A strategic, age-based approach ensures that treatments are not only aesthetically pleasing but also biologically appropriate.
By combining high-quality fillers with complementary regenerative therapies, practitioners can deliver long-lasting, natural results—and build lasting trust with patients at every stage of life.