Polynucleotides: Advancing Dermal Aesthetics

A Comprehensive Guide for Medical Professionals and How to Consult Patients

In the dynamic field of dermal aesthetics, polynucleotides have emerged as a cutting-edge treatment option. Available now at e-FILLERS, these bio-stimulators derived from purified DNA fragments, offer numerous benefits by enhancing collagen and elastin production. As a medical professional, understanding the science and application of polynucleotides is crucial for integrating this innovative solution into your practice and improving patient outcomes.

“Polynucleotides represent a significant advancement in dermal aesthetics, offering medical professionals a powerful tool for skin rejuvenation.”

The Science Behind Polynucleotides

Polynucleotides are powerful bio-stimulators that act at the cellular level to rejuvenate the skin. They work by boosting fibroblast cells, which in turn enhances the production of collagen and elastin—proteins essential for maintaining skin firmness and elasticity.

According to the report on the use of PN‐HPT™ in aesthetic medicine from Journal of Cosmetic Dermatology, long‐chain PN‐HPT™ gels are an innovative intradermal treatment strategy that combines a short‐time filling effect with biological proprieties that ease the recovery of and sound appearance the face and body skin areas where PN‐HPT™ are applied. In addition, PN‐HPT™ gels are highly biocompatible with a very low risk of adverse effects.

Over time, as these proteins diminish due to aging, the skin loses its youthful appearance. Polynucleotides counteract this process, promoting tissue regeneration and providing additional benefits such as antioxidant protection and enhanced hydration.

Mechanisms of Action

1. Stimulation of Fibroblasts

Polynucleotides promote fibroblast proliferation and activity, which are critical for the synthesis of collagen and elastin. This stimulation results in improved skin structure and resilience, addressing issues such as sagging and fine lines.

2. Tissue Regeneration

By encouraging cellular turnover and repair, polynucleotides facilitate the regeneration of damaged skin tissues. This leads to a reduction in scars, hyperpigmentation, and other skin imperfections, restoring a smoother and more uniform complexion.

3. Antioxidant Properties

Polynucleotides possess potent antioxidant capabilities, neutralizing free radicals and reducing oxidative stress. This protection is vital for preventing premature aging and environmental damage, which are common concerns among patients.

4. Hydration Enhancement

These bio-stimulators also improve the skin’s hydration levels by attracting and retaining moisture. This results in a plumper, more pumped skin appearance, which is essential for overall skin health and aesthetics.

Recommended Protocol for Polynucleotides Treatment on the Face

The benefits of skin priming and revitalization of face skin with PN‐HPT™ gels are most significant even in case of advanced skin aging provided the highest concentration PN‐HPT™ formulations is selected (intradermal injection of 40 mg/2 mL). It is strongly advised that patients receive the full content of 2 mL (all 40 mg) at each session, suggesting an intradermal injection every 14 or 21 days for a total of 4 sessions as initial treatment cycle.

Source: J Cosmet Dermatol. 2021 Mar; 20(3): 922–928.

Clinical Benefits for Patients

1. Improved Skin Elasticity and Firmness: Enhanced collagen and elastin production leads to firmer and more elastic skin.

2. Reduction of Fine Lines and Wrinkles: Tissue regeneration helps diminish the appearance of fine lines and wrinkles.

3. Even Skin Tone and Texture: The reparative properties of polynucleotides contribute to a more even skin tone and smoother texture.

4. Long-lasting Hydration: Increased moisture retention results in hydrated, healthy-looking skin.

5. Protection Against Oxidative Damage: Antioxidant effects protect the skin from environmental stressors.

Visit the e-FILLERS Library to learn more about polynucleotide products and how they can benefit your patients.

Integrating Polynucleotides into Your Practice

Patient Education

Educating patients about the benefits and mechanisms of polynucleotides is essential. Use detailed explanations and visual aids to illustrate how these treatments work at the cellular level. Emphasize the science behind collagen and elastin production and how polynucleotides stimulate these processes.

Tailored Treatment Plans

Assess each patient’s individual skin concerns and customize treatment plans accordingly. Explain how polynucleotides can address their specific issues, such as aging signs, skin laxity, and dehydration. Personalizing your approach ensures better patient satisfaction and outcomes.

Procedure Overview

Provide a comprehensive overview of the treatment procedure, including the number of sessions required, the expected results, and any necessary aftercare. Clear communication helps manage patient expectations and enhances their comfort with the process.

Addressing Concerns

Be prepared to answer common patient questions about safety, efficacy, and potential side effects. Share clinical data and research findings to reassure patients of the treatment's safety and success. Transparency and evidence-based information build trust and confidence.

Polynucleotides represent a significant advancement in dermal aesthetics, offering medical professionals a powerful tool for skin rejuvenation. By understanding their mechanisms of action and clinical benefits, you can effectively integrate polynucleotide treatments into your practice. This not only enhances patient outcomes but also positions your practice at the forefront of aesthetic innovation.

Stay ahead in the field of dermal aesthetics and provide your patients with the most advanced care options available.

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