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- Author e-FILLERS Team
- May 21st, 2025
Combining Fillers with Biorevitalization for Long-Lasting Results

In today’s aesthetic world, the most impressive results often come from a thoughtful combination of treatments. While dermal fillers remain a top choice for restoring volume and enhancing facial contours, many practitioners are now pairing them with biorevitalization treatments to target the skin’s overall quality. The result? Natural-looking, long-lasting outcomes that not only reshape but also rejuvenate.
Why Combine Fillers and Biorevitalizers?
Fillers are highly effective in adding structure, support, and definition to the face. Products like JUVÉDERM® VOLUMA® LIDOCAINE - 2x1ml , STYLAGE® Bi-SOFT XL 2x1ml, and TEOSYAL® PURESENSE ULTRA DEEP - 2x1,2ml are commonly used to restore lost volume in the cheeks, chin, and jawline, while lighter fillers address fine lines and subtle enhancements.
However, while fillers lift and volumize, they do not directly improve the skin's texture, tone, or hydration levels. That’s where biorevitalization treatments come in. Products like PROFHILO® h+L - 1x2ml and SUNEKOS® Performa 2x3,5ml work beneath the surface to stimulate collagen and elastin production, improve hydration, and enhance skin firmness from within.
By combining these two approaches, practitioners can deliver both structural enhancement and true skin rejuvenation—achieving a more holistic and harmonious result.
Strategic Layering: How It Works
The key to a successful combination treatment lies in strategic layering. Fillers are typically used to address areas with volume loss or contouring needs—such as the cheeks, nasolabial folds, jawline, and temples. Once the facial framework is restored, biorevitalizers are then applied to improve skin quality in surrounding areas, such as the mid-face, neck, or décolleté.
PROFHILO® h+L - 1x2ml, known for its high concentration of pure hyaluronic acid, spreads smoothly through the tissue and activates collagen remodeling without creating volume. This makes it an ideal follow-up after filler treatments. Similarly, SUNEKOS® Performa 2x3,5ml, which combines amino acids with HA, enhances elasticity and smooths fine lines—especially in delicate areas like the under-eyes or around the mouth.
For patients concerned with skin laxity, dullness, or early signs of aging, the addition of PhilArt or Plinest—both polynucleotide-based therapies—can deliver significant regenerative effects, enhancing skin vitality and promoting long-term dermal health.
Benefits of Combination Therapy
Pairing fillers with biorevitalization has become a go-to method for practitioners seeking to offer natural and sustained improvements. Among the top benefits:
Enhanced Results: The volumizing effect of fillers is amplified by improved skin hydration and tone.
Extended Longevity: Healthier skin may help maintain filler results longer and delay the need for additional treatments.
Full-Face Harmony: Treating both structure and surface ensures balanced, natural-looking outcomes.
Preventative Aging: Stimulating collagen and elastin preserves youthful qualities over time, reducing the need for aggressive treatments later on.
Ideal Candidates
This combination approach suits a wide range of patients—from those with early signs of aging to more mature individuals seeking comprehensive rejuvenation. Younger patients may benefit from low-volume fillers combined with skin-boosting injectables as a form of prevention, while older patients appreciate the dual action of lifting and revitalizing.
By combining the volumizing benefits of dermal fillers with the regenerative power of biorevitalizers, aesthetic practitioners can offer clients more than just a temporary fix. They can deliver results that are natural, subtle, and supported by improved skin health over time. Whether you're treating volume loss, skin laxity, or early wrinkles, blending structure with skin rejuvenation is the modern approach to lasting beauty.