Author e-FILLERS Team
Sep 25th, 2025

Combining Fillers with Other Aesthetic Treatments: What Works Best?

Dermal fillers have become a foundation of modern aesthetic medicine, restoring lost volume, enhancing contours, and creating youthful definition. But fillers are most effective when combined with complementary treatments that address skin quality, laxity, and overall harmony.

This article explores the most effective treatment pairings with fillers and outlines best practices for safe, natural, and lasting results.

Why Combine Treatments?

Comprehensive rejuvenation: Fillers restore structure, while other treatments improve texture, tone, and elasticity.
Synergy of results: Layered therapies can amplify outcomes without overcorrection.
Tailored solutions: A multimodal approach adapts to individual needs and goals.

Top Combinations That Work Best

1. Fillers + Skin Boosters (e.g., Profhilo®, Sunekos®)

Why: Fillers replace lost volume, while skin boosters improve hydration and elasticity.
Best use: Tear troughs, perioral region, décolleté, and hands.
Tip: Start with boosters, then refine with fillers for a complete rejuvenation.

2. Fillers + Biostimulators (e.g., Radiesse®, Sculptra®)

Why: Fillers give instant correction, while biostimulators trigger gradual collagen renewal.
Best use: Mid-face lift, jawline, temples.
Tip: Use fillers for immediate results and biostimulators for long-term structural improvement.

3. Fillers + Threads (PDO / PLLA)

Why: Threads reposition sagging tissue, fillers restore contour and balance.
Best use: Jawline contouring, cheek lift, and mid-face support.
Tip: Place threads first, then use fillers to fine-tune volume and symmetry.

4. Fillers + Energy-Based Devices (Laser, RF, HIFU)

Why: Devices tighten skin, reduce pigmentation, and refine texture; fillers provide volume and structure.
Best use: Lower face laxity, jowls, fine lines.
Tip: Perform device-based treatments before fillers to avoid disrupting filler placement.

5. Fillers + PRP/Exosomes

Why: PRP and exosomes enhance skin quality, healing, and regeneration, complementing the volumizing effect of fillers.
Best use: Tear troughs, acne scars, patients with thin or fragile skin.
Tip: Stage treatments over several sessions for cumulative improvement.

Safety Considerations

Always respect treatment order (e.g., energy devices before fillers, regenerative therapies staged separately).
Allow sufficient intervals between modalities to minimize side effects.
Prioritize reversible fillers (hyaluronic acid) in sensitive areas.
Manage expectations: explain how layered treatments work together over time.

Example of a Combination Treatment Plan

Week 1: Skin booster for hydration and elasticity.
Week 3: HA filler for mid-face or lips.
Week 6: Thread lift for definition.
Month 3: Energy-based treatment for tone and tightening.

This gradual plan avoids overtreatment and ensures natural, progressive results.

Key Takeaways

Fillers are powerful, but their results are maximized when paired with other aesthetic modalities.
Skin boosters, biostimulators, threads, energy devices, and regenerative therapies each add unique benefits.
Proper sequencing and personalization ensure safe, effective, and long-lasting outcomes.